Cost of Brand-Name Prescription Medicines Soaring





The price of brand-name prescription medicines is rising far faster than the inflation rate, while the price of generic drugs has plummeted, creating the largest gap so far between the two, according to a report published Wednesday by the pharmacy benefits manager Express Scripts.




The report tracked an index of commonly used drugs and found that the price of brand-name medicines increased more than 13 percent from September 2011 to this September, which it said was more than six times the overall price inflation of consumer goods. Generic drug prices dipped by nearly 22 percent.


The drop in the price of generics “represents low-hanging fruit for the country to save money on health care,” said Dr. Steve Miller, the chief medical officer of Express Scripts, which manages the drug benefits for employers and insurers and also runs a mail-order pharmacy.


The report was based on a random sample of six million Express Scripts members with prescription drug coverage.


The Pharmaceutical Research and Manufacturers of America, the trade group representing brand-name manufacturers, criticized the report, saying it was skewed by a handful of high-priced specialty drugs that are used by a small number of patients and overlooked the crucial role of major drug makers.


“Without the development of new medicines by innovator companies, there would be neither the new treatments essential to progress against diseases nor generic copies,” Josephine Martin, executive vice president of the group, said in a statement.


The report cited the growth of specialty drugs, which treat diseases like cancer and multiple sclerosis, as a major reason for the increase in spending on branded drugs. Spending on specialty medicines increased nearly 23 percent during the first three quarters of 2012, compared with the same period in 2011. All but one of the new medicines approved in the third quarter of this year were specialty drugs, the report found, and many of them were approved to treat advanced cancers only when other drugs had failed.


Stephen W. Schondelmeyer, a professor of pharmaceutical economics at the University of Minnesota, said the potential benefits of many new drugs did not always match the lofty price tags. “Increasingly it’s going to be difficult for drug-benefit programs to make decisions about coverage and payment and which drugs to include,” said Mr. Schondelmeyer, who conducts a similar price report for AARP. He also helps manage the drug benefit program for the University of Minnesota.


“We’re going to be faced with the issue that any drug at any price will not be sustainable.”


Spending on traditional medicines — which treat common ailments like high cholesterol and blood pressure — actually declined by 0.6 percent during the period, the report found. That decline was mainly because of the patent expiration of several blockbuster drugs, like Lipitor and Plavix, which opened the market for generic competitors. But even as the entry of generic alternatives pushed down spending, drug companies continued to raise prices on their branded products, in part to squeeze as much revenue as possible out of an ever-shrinking portfolio, Dr. Miller said.


Drug makers are also being pushed by companies like Express Scripts and health insurers, which are increasingly looking for ways to cut costs, said C. Anthony Butler, a pharmaceuticals analyst at Barclays. “I think they’re pricing where they can but what they keep telling me is they’re under significant pressure” to keep prices low, he said.


Express Scripts earns higher profits from greater use of generic medicines than brand name drugs sold through their mail-order pharmacy, Mr. Butler said. “There’s no question that they would love for everybody to be on a generic,” he said.


Dr. Miller acknowledged that was true but said that ultimately, everyone wins. “When we save people money, that’s when we make money,” he said. “We don’t shy away from that.”


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New York Fed president sees greater impact from Sandy









NEW YORK -- Superstorm Sandy appears to have damaged the New York area's economy more than initially believed, New York Federal Reserve president William Dudley said.


Although the monster storm's impact has yet to be fully measured, Sandy's toll on labor markets, manufacturing and the area's infrastructure appears to be "more extensive and longer-lasting than first anticipated," Dudley said in a speech prepared for delivery at Pace University.


Every firm that responded to the New York Fed's manufacturing survey reported an impact from Sandy, with 40% indicating that the storm shut down or severely crippled their operations for at least five days.





The number of workers filing initial claims for unemployment insurance tripled in New York and New Jersey, Dudley added, suggesting the storm has cost at least 70,000 jobs in the two states so far.


Losses, in dollars, could be huge. The region contributes $1.4 trillion of the country's gross domestic product, or $3.8 billion a day, Dudley said.


"These data suggest that the disruptions that we have seen, and continue to see, could be substantial," Dudley said. 


Still, rebuilding could help offset Sandy's economic drag.


"Past studies suggest that reconstruction spending provides a powerful stimulus to local economies, both in its direct effects and its associated multiplier effects," Dudley said. "Thus, I expect that reconstruction will provide a similar sizable boost to our regional economic activity, and one that is likely to continue well into 2013."


ALSO:


GDP is revised higher, but large risks threaten outlook


Initial jobless claims dropped again last week after Sandy 


Mortgage rates level off near record low, Freddie Mac says 





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Norquist: GOP concern over tax pledge just 'impure thoughts'









Grover Norquist on Wednesday rebuffed claims that his anti-tax crusade is losing steam, calling statements from prominent Republicans hinting at their departure from his anti-tax pledge "impure thoughts."

Norquist, president of Americans for Tax Reform, met with Politico’s Mike Allen to offer his thoughts on the looming “fiscal cliff,” and the growing narrative that Republicans, after years of tying themselves to ATR’s pledge not to raise taxes, may be ready to jump ship.


Most recently, Rep. Tom Cole (R-Okla.) said in a private meeting with the House Republican whip team Tuesday morning that Republicans should take the opportunity to extend President George W. Bush’s tax cuts for 98% of Americans, calling it an “early Christmas present” for taxpayers.


And on Sunday, Sen. Lindsay Graham (R-S.C.) and Rep. Peter King (R-N.Y.) joined Sen. Saxby Chambliss (R-Ga.) in voicing concern over continued adherence to Norquist’s pledge.





House Speaker John A. Boehner (R-Ohio) responded to Cole on Wednesday, saying that though Cole is a friend and supporter, he disagrees entirely with his stance. “The goal here is to grow the economy and control spending. You’re not going to grow the economy if you raise tax rates on the top two rates,” Boehner said.


Though Norquist commented that Cole’s recommendation was “an interesting tactic,” he remained firm that his pledge remains viable, saying that anyone suggesting that opposing tax increases is no longer in vogue is “an idiot.”


The pledge, Norquist claimed, “takes weasel words out” of campaign promises to cut taxes, and provides voters a clear picture of a candidate's stance, a stance he said the Republican Party has built its brand upon.


Norquist said that signing the pledge is about informing voters and entrenching a preexisting policy stance, instead of an oath of fealty to ATR and its champion cause.


“They don’t need my permission to raise taxes,” he said, adding that such power lies in the hands of voters.


And he dismissed claims that the pledge’s powers extend beyond the promises tied to its concise wording.


“It doesn’t solve all of the world’s problems; it doesn’t design tax reform,” Norquist said.


But Norquist did design a general road map for Republicans to use in fiscal cliff negotiations.


“You need to have this conversation in public, you need to be online so you can have the moral higher ground,” he said, recommending that the GOP aim for a temporary extension of Bush’s tax cuts, with comprehensive tax reform to follow soon after.


“If the Republicans lose in such a way that they have their fingerprints on the murder weapon, then you have a problem,” he said, adding that public debate over the fiscal cliff would allow Republicans a chance to turn the tide against President Obama and the Democrats, so long as they maintain “credible clarity” in espousing their low-tax vision.


Norquist said he worries about conceding any ground to Democrats on tax increases.


“What the Democrats do is trickle-down taxation,” he said. “They tax the rich and then they screw everybody.”


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ABC celebrating Dick Clark on New Year's Eve

NEW YORK (AP) — ABC is turning its first New Year's Eve without Dick Clark in four decades partly into a celebration of the showbiz impresario's life.

Clark, who did the first annual "New Year's Rockin' Eve" special on ABC in 1972, died at age 82 in April. Fergie and Jenny McCarthy will be hosts of a two-hour tribute to Clark that will air at 8 p.m. ET on New Year's Eve.

ABC said Wednesday that Ryan Seacrest will host the countdown show from Times Square, with Taylor Swift, Carly Rae Jepsen, Neon Trees, Flo Rida and Pitbull among the musical guests. Seacrest hosted the past few years with Clark making short appearances. A stroke had diminished Clark's communications skills.

Al Green, Helen Reddy and Three Dog Night performed at Clark's first New Year's special.

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Well: Weight Loss Surgery May Not Combat Diabetes Long-Term

Weight loss surgery, which in recent years has been seen as an increasingly attractive option for treating Type 2 diabetes, may not be as effective against the disease as it was initially thought to be, according to a new report. The study found that many obese Type 2 diabetics who undergo gastric bypass surgery do not experience a remission of their disease, and of those that do, about a third redevelop diabetes within five years of their operation.

The findings contrast the growing perception that surgery for many diabetics could be something of a cure. Earlier this year, two widely publicized studies reported that surgery worked better than drugs, diet and exercise in causing a remission of Type 2 diabetes in overweight people whose blood sugar was out of control, leading some experts to call for greater use of surgery in treating the disease. But the studies were small and relatively short, lasting under two years.

The latest study, published in the journal Obesity Surgery, tracked thousands of diabetics who had gastric bypass surgery for more than a decade. It found that many people whose diabetes at first went away were likely to have it return. While weight regain is a common problem among those who undergo bariatric surgery, regaining lost weight did not appear to be the cause of diabetes relapse. Instead, the study found that people whose diabetes was most severe or in its later stages when they had surgery were more likely to have a relapse, regardless of whether they regained weight.

“Some people are under the impression that you have surgery and you’re cured,” said Dr. Vivian Fonseca, the president for medicine and science for the American Diabetes Association, who was not involved in the study. “There have been a lot of claims about how wonderful surgery is for diabetes, and I think this offers a more realistic picture.”

The findings suggest that weight loss surgery may be most effective for treating diabetes in those whose disease is not very advanced. “What we’re learning is that not all diabetic patients do as well as others,” said Dr. David E. Arterburn, the lead author of the study and an associate investigator at the Group Health Research Institute in Seattle. “Those who are early in diabetes seem to do the best, which makes a case for potentially earlier intervention.”

One of the strengths of the new study was that it involved thousands of patients enrolled in three large health plans in California and Minnesota, allowing detailed tracking over many years. All told, 4,434 adult diabetics were followed between 1995 and 2008. All were obese, and all underwent Roux-en-Y operations, the most popular type of gastric bypass procedure.

After surgery, about 68 percent of patients experienced a complete remission of their diabetes. But within five years, 35 percent of those patients had it return. Taken together, that means that most of the subjects in the study, about 56 percent — a figure that includes those whose disease never remitted — had no long-lasting remission of diabetes after surgery.

The researchers found that three factors were particularly good predictors of who was likely to have a relapse of diabetes. If patients, before surgery, had a relatively long duration of diabetes, had poor control of their blood sugar, or were taking insulin, then they were least likely to benefit from gastric bypass. A patient’s weight, either before or after surgery, was not correlated with their likelihood of remission or relapse.

In Type 2 diabetes, the beta cells that produce insulin in the pancreas tend to wear out as the disease progresses, which may explain why some people benefit less from surgery. “If someone is too far advanced in their diabetes, where their pancreas is frankly toward the latter stages of being able to produce insulin, then even after losing a bunch of weight their body may not be able to produce enough insulin to control their blood sugar,” Dr. Arterburn said.

Nonetheless, he said it might be the case that obese diabetics, even those whose disease is advanced, can still benefit from gastric surgery, at least as far as their quality of life and their risk factors for heart disease and other complications are concerned.

“It’s not a surefire cure for everyone,” he said. “But almost universally, patients lose weight after weight loss surgery, and that in and of itself may have so many health benefits.”

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Dutch court sides with Apple, bans some Samsung Galaxy products













Apple and Samsung


Apple and Samsung continue to joust over every detail of their respective smartphones.
(Damien Meyer)































































If you thought the patent wars between Apple and Samsung couldn't possibly get any more mind-numbingly obscure, you would be wrong.


Today, a Dutch court handed Apple another victory when it decided to ban some Samsung smartphones and tablets because they still violate a patent for scrolling across photos on a touchscreen device. The ban covers the Samsung Galaxy S, SII and Ace.


Actually, Samsung had already lost this battle once, when the judges ruled previously that some of its gadgets had run afoul of Apple's patent. Samsung struck back by changing the technology it uses. Or, so it claimed.





But the Dutch court didn't buy it. In fact, the judges were more than a little annoyed that the Samsung lawyers came to a hearing without evidence that the change had been made, according to CIO.com:  


"And now at the hearing you come without any substantiation with the bare assertion that this is the case and that we should believe you?" asked Rian Kalden, one of three judges reviewing the case.

For those of you watching the battle to win supremacy of the smartphone and tablet market in the Netherlands, well, know that Apple has gained even more leverage over its South Korean nemesis. For the rest of us, however, this is the latest demonstration of how both sides are unwilling to cede an inch of territory in their intellectual property war of attrition. 


For the true smartphone-patent-war obsessive, grab your Dutch-to-English dictionary and read the actual ruling here.


Follow me on Twitter @obrien.






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Cyber Monday sales up 17% to nearly $2 billion, exceeding forecast









Cyber Monday online sales beat forecasts by nearly half a billion dollars.


ComScore on Monday predicted that Cyber Monday would generate $1.5 billion in online sales, but according to Adobe, the shopping day ended up raking in $1.98 billion, which was a 17% increase compared to last year.


That practically doubled online Black Friday sales, which topped $1 billion this year for the first time, according to ComScore.





Video chat: Finding deals on Cyber Monday


And if Cyber Monday's online sales weren't impressive enough, Adobe says that mobile shopping doubled from last year and accounted for 22% of Cyber Monday sales.


On the opposite end of that spectrum was social, which referred only a dismal 2% of total site visits on Cyber Monday. Even worse for Facebook and Twitter is the fact their number of referrals stayed the same as last year's, while Pinterest's referrals for the holiday grew 105%, accounting for 15% of social referrals.


As for what people were buying, Adobe said that toys and sporting goods led the way, followed by health and beauty. Home and auto was the third most selling category.


Adobe said you can follow its tracking of online holiday shopping with this tool, which keeps track of current sales and estimates how the rest of the holiday shopping days will fare.


ALSO:


Internet surfing while driving is on the rise


Apple's new ultra-thin iMac goes on sale Friday


Tumblr now among top 10 U.S. sites with 168 million global users





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Disney Channel to debut 'Sofia the First' Jan. 11

NEW YORK (AP) — Disney says its animated children's series "Sofia the First" will premiere Jan. 11 on the Disney Channel and Disney Junior networks.

Created for kids ages 2 to 7, "Sofia the First" is about a young girl who becomes a princess and learns that honesty, loyalty and compassion are what makes a person royal.

Sofia is voiced by "Modern Family" actress Ariel Winter, and her mother is played by "Grey's Anatomy" star Sara Ramirez.

Last week's premiere of the "Sofia the First" animated movie drew a total audience of more than 5 million viewers. It was the year's top-rated cable TV telecast among kids ages 2 to 5.

In the series' debut episode, Sofia strives to become the first princess to earn a spot on her school's flying derby team.

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Global Update: Investing in Eyeglasses for Poor Would Boost International Economy


BSIP/UIG Via Getty Images







Eliminating the worldwide shortage of eyeglasses could cost up to $28 billion, but would add more than $200 billion to the global economy, according to a study published last month in the Bulletin of the World Health Organization.


The $28 billion would cover the cost of training 65,000 optometrists and equipping clinics where they could prescribe eyeglasses, which can now be mass-produced for as little as $2 a pair. The study was done by scientists from Australia and the Johns Hopkins Bloomberg School of Public Health.


The authors assumed that 703 million people worldwide have uncorrected nearsightedness or farsightedness severe enough to impair their work, and that 80 percent of them could be helped with off-the-rack glasses, which would need to be replaced every five years.


The biggest productivity savings from better vision would not be in very poor regions like Africa but in moderately poor countries where more people have factory jobs or trades like driving or running a sewing machine.


Without the equivalent of reading glasses, “lots of skilled crafts become very difficult after age 40 or 45,” said Kevin Frick, a Johns Hopkins health policy economist and study co-author. “You don’t want to be swinging a hammer if you can’t see the nail.”


If millions of schoolchildren who need glasses got them, the return on investment could be even greater, he said, but that would be in the future and was not calculated in this study.


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Cyber Monday sales up 17% to nearly $2 billion, exceeding forecast









Cyber Monday online sales beat forecasts by nearly half a billion dollars.


ComScore on Monday predicted that Cyber Monday would generate $1.5 billion in online sales, but according to Adobe, the shopping day ended up raking in $1.98 billion, which was a 17% increase compared to last year.


That practically doubled online Black Friday sales, which topped $1 billion this year for the first time, according to ComScore.





Video chat: Finding deals on Cyber Monday


And if Cyber Monday's online sales weren't impressive enough, Adobe says that mobile shopping doubled from last year and accounted for 22% of Cyber Monday sales.


On the opposite end of that spectrum was social, which referred only a dismal 2% of total site visits on Cyber Monday. Even worse for Facebook and Twitter is the fact their number of referrals stayed the same as last year's, while Pinterest's referrals for the holiday grew 105%, accounting for 15% of social referrals.


As for what people were buying, Adobe said that toys and sporting goods led the way, followed by health and beauty. Home and auto was the third most selling category.


Adobe said you can follow its tracking of online holiday shopping with this tool, which keeps track of current sales and estimates how the rest of the holiday shopping days will fare.


ALSO:


Internet surfing while driving is on the rise


Apple's new ultra-thin iMac goes on sale Friday


Tumblr now among top 10 U.S. sites with 168 million global users





Read More..