F.D.A. Requires Cuts to Dosages of Ambien and Other Sleep Drugs





The Food and Drug Administration announced on Thursday that it was requiring manufacturers of popular sleeping pills like Ambien and Zolpimist to cut their recommended dosage in half for women, after laboratory studies showed that they can leave people still sleepy in the morning and at risk for accidents.


The agency issued the requirement for drugs containing the active ingredient zolpidem, by far the most widely used sleep aid. Using lower doses means less of the drug will remain in the blood in the morning hours, and leave people who take it less exposed to the risk of impairment while driving to work.


Women eliminate zolpidem from their bodies more slowly than men and the agency told manufacturers that the recommended dosage for women should be lowered to 5 milligrams from 10 milligrams for immediate-release products like Ambien, Edluar and Zolpimist. Dosages for extended-release products should be lowered to 6.25 milligrams from 12.5, the agency said. The agency also recommended lowering dosages for men.


An estimated 10 to 15 percent of women will have a level of zolpidem in their blood that impairs driving eight hours after taking the pill, while only about 3 percent of men do, said Dr. Robert Temple, deputy director for clinical science in the F.D.A.'s Center for Drug Evaluation and Research.


Doctors will still be told that they can prescribe the higher dosage if the lower one does not work, Dr. Temple said.


“Most people thought that by the morning it is gone,” he said. “What we’re reminding people is that is sort of true, but that in some women who take a full 10 milligram dose, and in a lot of people who take the control release dose, it is not entirely true. Some people will be impaired in the morning.”


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Investors, Starbucks co-bidder oppose McDreamy's Tully's buy









It’s not just the “Grey’s Anatomy” mid-season premiere Thursday night weighing on Patrick Dempsey’s mind – the would-be coffee company owner is facing several objections to his pending purchase of Seattle’s Tully’s chain.


Last week, the actor known as McDreamy triumphantly announced that his group Global Baristas’ $9.15-million bid for Tully’s was deemed the winner by the bankrupt company.


Several of the six other bidders, however, now say they won’t go away without a tussle.





AgriNuture Inc., a food producer and distributor based in the Philippines, wrote in a Seattle bankruptcy court this week that it was willing to proceed with its bid.


The company’s offer, when combined with Starbucks Corp.’s proposal to transition 25 Tully’s shops to its own brand, amounts to $10.56 million – or $1.35 million more than Dempsey’s.   


AgriNuture, which runs six Tully’s franchises in the Philippines, noted in the filing that it “understands that Starbucks is prepared to proceed.”


Finance group Kachi Partners, which managed the stalking horse bid for Tully’s from Neon T Coffee Shops, filed a separate document contesting Dempsey’s purported victory.


The Jan. 3 auction for Tully’s “had substantial irregularities and the purchase price, to the benefit of all the Debtor’s constituents, could have been – and could still be – at least $1.4 million higher,” wrote Kachi Partners spokesman Shawn Hallinan in the filing.


Investor Tom T. O’Keefe, who wrote in yet another filing that he owns more than 5% of Tully’s common stock, said he supported “restarting of the competitive bids.”


A Seattle bankruptcy judge is scheduled to make a final call Friday on the Tully’s purchase.


“We remain confident that the Court will reach the right decision and find that Global Baristas, LLC submitted the highest and best bid,” Dempsey said in a statement.  “The company chose between three final bids, and ours was millions more than each of the other two.”


ALSO:


Yum Brands apologizes for KFC chicken scare in China


Supervalu sells grocery chains, including Albertsons, to Cerberus


Patrick Dempsey beats Starbucks, will pay $9.15 million for Tully's





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LAPD says serial killer suspect may have more victims









Los Angeles police officials said they plan to comb through scores of old unsolved murders to see whether a reputed 72-year-old serial killer carried out slayings in the city beyond the three women he is suspected of killing in the 1980s.


Samuel Little, who authorities allege also killed women in Florida and Mississippi, currently is being held at California's Wasco state prison. He was charged Monday and is expected to return to Los Angeles for arraignment this week on the counts of murder with special circumstances.


LAPD's cold case homicide detectives now plan to take a methodical look at evidence from scores of unsolved murder and death cases dating back to the 1980s and early 1990s to determine whether Little may have been involved.








Prosecutors have charged Little in connection to three L.A. killings that appear to be sexually motivated strangulations: Carol Alford, 41, found dead on July 13, 1987; Audrey Nelson, 35, whose body was discovered Aug. 14, 1989; and Guadalupe Apodaca, 46, found Sept. 2, 1989. Their bodies were discovered in the Central Avenue-Alameda Street corridor, just south of downtown, although police have not released the exact locations where the victims were found.


LAPD detectives Mitzi Roberts and Rick Jackson, who investigated the cases, said there is DNA evidence linking Little, but declined to elaborate further because of the ongoing investigation. Roberts and Jackson spent months criss-crossing the country following Little’s path.


Two years ago, the LAPD arrested a man they said was the notorious “Grim Sleeper,” allegedly responsible for at least 10 slayings in South L.A. After his arrest, LAPD detectives examined hundreds of unsolved deaths involving women in the city with "high-risk lifestyles."


Detectives said they will focus on sexually motivated strangulations. But they also expect inquiries from law enforcement agencies around the country because Little has a criminal record in 24 states dating back to the 1950s.


Detectives said they believe he committed thefts during the day to make money to finance the bar-hopping that brought him into contact with his alleged victims.


“It was theft by day and murder by night,” Jackson said.


Little, who also used the name Samuel McDowell, served relatively little time in state prison or county jail, the detectives said. In the early 1980s, he was accused of two murders and two attempted murders in Gainesville, Fla., and Pascagoula, Miss.


Little was acquitted by a Florida jury in the strangulation death of Patricia Ann Mount, 26, whose body was discovered Sept. 12, 1982.


He was never brought to trial in the Mississippi cases, which include the strangulation death of Melinda LaPree, 24, on Sept. 14, 1982. That case has been reopened by the Pascagoula Police Department in light of new evidence, authorities said.


Little moved from the South to California in the mid-1980s, settling first in San Diego.


He served more than two years in state prison after being convicted of assault and false imprisonment of two San Diego women in separate cases, police said. Shortly after being paroled, he moved to Los Angeles.





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Why bother with a Facebook phone? Facebook’s app is already on 86% of iPhones and iPads






Rumors suggesting Facebook (FB) is working on a smartphone have resurfaced a number of times over the past year. Each time, Facebook denied the various claims. Facebook may indeed still be working on its own phone but as a new report from market research firm NPD Group shows, it probably doesn’t need to.


[More from BGR: Is Samsung the new Apple?]






Facebook makes money by gathering information about its users and serving targeted ads based on that data. Allowing users to update Facebook with fresh data as often as possible is obviously beneficial to the company, and smartphones present a terrific opportunity to give users access to their Facebook accounts from anywhere. The more people using Facebook’s mobile apps, the better, and Facebook’s smartphone penetration is absolutely staggering right now.


[More from BGR: iPhone 5 now available with unlimited service, no contract on Walmart’s $ 45 Straight Talk plan]


According to data published by NPD Group on Tuesday, Facebook’s iOS application was used by 86% of iPhone, iPad and iPod touch owners as of November 2012. On the Android platform, 70% of smartphone and tablet owners used Facebook’s mobile app in November.


No other third-party app even comes close to approaching Facebook’s mobile penetration. Google’s (GOOG) YouTube app is the next most popular third-party app on iOS with 40% penetration and Amazon’s (AMZN) mobile application is the second most popular third-party Android app with just 28% penetration.


So why would Facebook bother making its own phone?


One answer — perhaps the obvious one — is that an own-brand smartphone with custom software would give Facebook access to far more personal data than it can reach using third-party applications. Considering Facebook’s track record with matters relating to privacy, however, users may be reluctant to buy a Facebook phone.


In any case, a Facebook phone certainly doesn’t seem like a necessity for the time being. Instead, focusing on ways to effectively monetize the hundreds of millions of users who interact with Facebook from a smartphone or tablet each month might be a wiser use of resources.


This article was originally published on BGR.com


Social Media News Headlines – Yahoo! News




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Yoda statue among features of new N. Calif. park


SAN ANSELMO, Calif. (AP) — A Northern California city has approved a new downtown park to be built on land donated by filmmaker George Lucas that will feature statues of Indiana Jones and Yoda, two of his most popular characters.


The Marin Independent Journal reports (http://bit.ly/Ws4CcS ) that the San Anselmo Planning Commission voted unanimously Monday to approve the park, which could be completed as soon as June 1.


Lucas donated land for the 8,700-square-foot park. A commercial building on the site will be demolished at Lucas' expense, and an historic fresco relocated.


A fund is being established by a community foundation to pay for ongoing maintenance and care of the park.


The park's Yoda fountain will be similar to the one located at the Letterman Digital Arts Center in San Francisco.


___


Information from: Marin Independent Journal, http://www.marinij.com


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Economic Scene: Health Care and Pursuit of Profit Make a Poor Mix





Thirty years ago, Bonnie Svarstad and Chester Bond of the School of Pharmacy at the University of Wisconsin-Madison discovered an interesting pattern in the use of sedatives at nursing homes in the south of the state.




Patients entering church-affiliated nonprofit homes were prescribed drugs roughly as often as those entering profit-making “proprietary” institutions. But patients in proprietary homes received, on average, more than four times the dose of patients at nonprofits.


Writing about his colleagues’ research in his 1988 book “The Nonprofit Economy,” the economist Burton Weisbrod provided a straightforward explanation: “differences in the pursuit of profit.” Sedatives are cheap, Mr. Weisbrod noted. “Less expensive than, say, giving special attention to more active patients who need to be kept busy.”


This behavior was hardly surprising. Hospitals run for profit are also less likely than nonprofit and government-run institutions to offer services like home health care and psychiatric emergency care, which are not as profitable as open-heart surgery.


A shareholder might even applaud the creativity with which profit-seeking institutions go about seeking profit. But the consequences of this pursuit might not be so great for other stakeholders in the system — patients, for instance. One study found that patients’ mortality rates spiked when nonprofit hospitals switched to become profit-making, and their staff levels declined.


These profit-maximizing tactics point to a troubling conflict of interest that goes beyond the private delivery of health care. They raise a broader, more important question: How much should we rely on the private sector to satisfy broad social needs?


From health to pensions to education, the United States relies on private enterprise more than pretty much every other advanced, industrial nation to provide essential social services. The government pays Medicare Advantage plans to deliver health care to aging Americans. It provides a tax break to encourage employers to cover workers under 65.


Businesses devote almost 6 percent of the nation’s economic output to pay for health insurance for their employees. This amounts to nine times similar private spending on health benefits across the Organization for Economic Cooperation and Development, on average. Private plans cover more than a third of pension benefits. The average for 30 countries in the O.E.C.D. is just over one-fifth.


We let the private sector handle tasks other countries would never dream of moving outside the government’s purview. Consider bail bondsmen and their rugged sidekicks, the bounty hunters.


American TV audiences may reminisce fondly about Lee Majors in “The Fall Guy” chasing bad guys in a souped-up GMC truck — a cheap way to get felons to court. People in most other nations see them as an undue commercial intrusion into the criminal justice system that discriminates against the poor.


Our reliance on private enterprise to provide the most essential services stems, in part, from a more narrow understanding of our collective responsibility to provide social goods. Private American health care has stood out for decades among industrial nations, where public universal coverage has long been considered a right of citizenship. But our faith in private solutions also draws on an ingrained belief that big government serves too many disparate objectives and must cater to too many conflicting interests to deliver services fairly and effectively.


Our trust appears undeserved, however. Our track record suggests that handing over responsibility for social goals to private enterprise is providing us with social goods of lower quality, distributed more inequitably and at a higher cost than if government delivered or paid for them directly.


The government’s most expensive housing support program — it will cost about $140 billion this year — is a tax break for individuals to buy homes on the private market.


According to the Tax Policy Center, this break will benefit only 20 percent of mostly well-to-do taxpayers, and most economists agree that it does nothing to further its purported goal of increasing homeownership. Tax breaks for private pensions also mostly benefit the wealthy. And 401(k) plans are riskier and costlier to administer than Social Security.


From the high administrative costs incurred by health insurers to screen out sick patients to the array of expensive treatments prescribed by doctors who earn more money for every treatment they provide, our private health care industry provides perhaps the clearest illustration of how the profit motive can send incentives astray.


By many objective measures, the mostly private American system delivers worse value for money than every other in the developed world. We spend nearly 18 percent of the nation’s economic output on health care and still manage to leave tens of millions of Americans without adequate access to care.


Britain gets universal coverage for 10 percent of gross domestic product. Germany and France for 12 percent. What’s more, our free market for health services produces no better health than the public health care systems in other advanced nations. On some measures — infant mortality, for instance — it does much worse.


In a way, private delivery of health care misleads Americans about the financial burdens they must bear to lead an adequate existence. If they were to consider the additional private spending on health care as a form of tax — an indispensable cost to live a healthy life — the nation’s tax bill would rise to about 31 percent from 25 percent of the nation’s G.D.P. — much closer to the 34 percent average across the O.E.C.D.


A quarter of a century ago, a belief swept across America that we could reduce the ballooning costs of the government’s health care entitlements just by handing over their management to the private sector. Private companies would have a strong incentive to identify and wipe out wasteful treatment. They could encourage healthy lifestyles among beneficiaries, lowering use of costly care. Competition for government contracts would keep the overall price down.


We now know this didn’t work as advertised. Competition wasn’t as robust as hoped. Health maintenance organizations didn’t keep costs in check, and they spent heavily on administration and screening to enroll only the healthiest, most profitable beneficiaries.


One study of Medicare spending found that the program saved no money by relying on H.M.O.’s. Another found that moving Medicaid recipients into H.M.O.’s increased the average cost per beneficiary by 12 percent with no improvement in the quality of care for the poor. Two years ago, President Obama’s health care law cut almost $150 billion from Medicare simply by reducing payments to private plans that provide similar care to plain vanilla Medicare at a higher cost.


Today, again, entitlements are at the center of the national debate. Our elected officials are consumed by slashing a budget deficit that is expected to balloon over coming decades. With both Democrats and Republicans unwilling to raise taxes on the middle class, the discussion is quickly boiling down to how deeply entitlements must be cut.


We may want to broaden the debate. The relevant question is how best we can serve our social needs at the lowest possible cost. One answer is that we have a lot of room to do better. Improving the delivery of social services like health care and pensions may be possible without increasing the burden on American families, simply by removing the profit motive from the equation.


E-mail: eporter@nytimes.com;


Twitter: @portereduardo



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Wall Street gains as earnings flow in; Alcoa up









Stocks rose on Wall Street Wednesday after U.S. corporate earnings reports got off to a good start.

The Dow Jones industrial average rose 86 points to 13,415 as of noon EST. The Dow is coming off of two days of losses.

The Standard & Poor's 500 index gained six points to 1,463 and the Nasdaq composite rose 17 points to 3,109.

Stocks, having rallied after a last-minute resolution stopped the U.S. going from over the “fiscal cliff,” are facing their first challenge of the year as companies start to report their earnings for the fourth quarter of 2012. Throughout last year, analysts had cut their outlook for earnings growth in the period and now expect them to rise by 3.21 percent, according to data from S&P Capital IQ.

“Maybe earnings expectations were a little too low,” said Ryan Detrick, a strategist at Schaeffer's Investment Research. “You don't need to have great earnings, you just need to beat those expectations” for stocks to rally, Detrick said.

Alcoa predicted rising demand for aluminum this year as the aerospace industry gains strength. Late Tuesday the company reported fourth-quarter revenue that beat analysts' estimates. Investors pay close attention to Alcoa's results and forecasts because the aluminum it makes is used in so many industries including construction and manufacturing.

Alcoa's stock rose 8 cents to $9.18.

Consumer products maker Helen of Troy, whose brands include Dr. Scholl's, Vicks and Fabreze, rose 89 cents to $34.42 after reporting a 15 percent increase in net income. Agricultural products giant Monsanto gained 84 cents to $99.34 after it said that its profit nearly tripled in the first fiscal quarter as sales of its biotech corn seeds expanded in Latin America.

The yield on the 10-year Treasury note was unchanged at 1.87 percent.

Among other stocks making big moves:

— Wireless network operator Clearwire jumped 22 cents to $3.14 after Dish network made an unsolicited offer to buy the company, which has already agreed to sell itself to Sprint. Dish rose $1.17 to $37.14 and Sprint fell 8 cents to $5.89.

— Online education company Apollo Group plunged 10 percent after reporting a sharp decline in fall-term student sign-ups at the University of Phoenix. The stock fell $2.04 to $18.88.

— Seagate Technology, a maker of hard-disk drives, jumped $1.52 to $32.91 after predicting revenue for its fiscal second quarter that topped Wall Street expectations late Tuesday.

— Bank of America fell 29 cents to $11.69 after Credit Suisse analysts lowered their outlook on the lender to “neutral” for “outperform,” saying the current stock price overestimates the improvement in cost reduction that the bank can achieve this year.

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Testimony about Colorado massacre resumes in James Holmes hearing

More emotional testimony was expected at a hearing on the Aurora movie theater massacre, as prosecutors continued to lay out their case against the defendant, James Holmes.









CENTENNIAL, Colo. — Vivid testimony about the movie theater massacre that shocked a nation extended into a second day as a preliminary hearing for James E. Holmes resumed Tuesday.


Prosecutors continued to lay out their case against Holmes, 25, accused of killing 12 people and injuring about 70 during a shooting rampage on July 20 in a suburban cinema. At issue in the proceeding, expected to last a week, is whether there is a sufficient case to go to trial.


In the first day of testimony Monday, law enforcement officials described the bloody shooting scene and heartbreaking rescue attempts to bring the gravely wounded to treatment.








PHOTOS: Colorado movie theater shooting


The prosecution has been trying to show that Holmes acted deliberately while the defense in cross-examination has focused on how the former neuroscience graduate student appeared emotionally detached, bolstering their expected insanity presentation.


Throughout, Holmes has sat impassive, while some of the victims' relatives have wept during the more graphic testimony.

On Tuesday, the atmosphere at the Arapahoe County Court House contained less of the frenzy that marked the first day. Yet the proceedings come as the debate over gun control has heated up in the wake of the attack last month in Newtown, Conn., in which 20 children and six adults were killed by a lone gunman who invaded the Sandy Hook Elementary School. The gunman first killed his mother in their home and ended his shooting spree by killing himself.


WHO THEY WERE: Aurora theater shooting


Tuesday’s testimony also comes as the nation commemorates the second anniversary of the Tucson shooting where six died and 13 were injured when gunman Jared Lee Loughner opened fire in a supermarket parking lot where former Rep. Gabrielle Giffords was holding a meet-and-greet with her constituents. Tucson, which has had events for several days, will mark the exact time of the shooting with the ringing of bells across the city at the moment of the morning attack.


Giffords, who went through a painful recovery and rehabilitation for gun wounds to the head, has become a spokeswoman for greater gun control. She and her husband, former astronaut Mark Kelly, announced they would raise money to support gun control efforts. The pair visited Newtown last week.


On Monday, Aurora police testified about the horrors they found in the theater, including blood-soaked aisles and walls, crumpled bodies, and scores of spent shell casings.

TIMELINE: U.S. mass shootings


The prosecution also showed surveillance video of Holmes entering the theater complex just past midnight. He had purchased his ticket 12 days earlier. The chilling, soundless video shows Holmes redeeming his ticket at a kiosk, giving it to a ticket taker, then lingering near the concession stand for a few minutes before turning toward Theater 9, where the Batman movie, “The Dark Knight Rises” was playing.


Prosecutors have yet to announce whether they will seek the death penalty.


ALSO:


Supreme Court rejects challenge to Obama stem cell policy


Chicago man fatally poisoned a month after hitting lotto jackpot


Alabama police: High school white supremacist planned bomb attack


Deam reported from Centennial, Colo.; Muskal reported from Los Angeles. 








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Target to match some rivals’ online prices year-round






(Reuters) – Target Corp said on Tuesday it will match on a year-round basis the prices found on the websites of key rivals Amazon.com Inc, Best Buy Co Inc, Wal-Mart Stores Inc and Toys R Us, its latest tactic to hold onto shoppers focused on price.


The move extends an online price-matching program that Target introduced over the holiday season and which was supposed to last only from November 1 to December 16. It also comes after Target last week reported flat sales growth in December at stores open at least a year.






In November Chief Executive Gregg Steinhafel said the retailer was not seeing a lot of price-match activity in its stores.


While shopping online has grown rapidly in recent years, it still represents a small fraction of overall shopping in the United States. Target’s policy of matching online prices differs from policies at several chains, which match only printed advertised prices for items sold at stores.


Target said that throughout the year it will match the price when a customer buys an eligible item at one of its stores and finds the same item at a lower price in the following week’s Target circular or in a local competitor’s printed ad. It will also match the price if the customer finds the same item at a lower price within a week on Target’s website or the websites of Amazon, Walmart, Best Buy and Toys R Us.


Amazon says it offers competitive prices and does not offer price matching when an item’s price drops after a customer buys it, with the exception of televisions. Walmart matches the prices of print ads from competitors. Walmart also says it checks the prices of 30,000 items at competing chains each week to make sure it has the lowest prices.


Best Buy matches the price from a local competitor’s store, a local Best Buy store or its own web site. Toys R Us matches in-store prices and certain online prices.


(Reporting By Jessica Wohl in Chicago and Phil Wahba in New York; Editing by Alden Bentley and John Wallace)


Internet News Headlines – Yahoo! News





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Spielberg earns 11th Directors Guild nomination


LOS ANGELES (AP) — Steven Spielberg has extended his domination at the Directors Guild of America Awards, earning a nomination Tuesday for his Civil War epic "Lincoln" to pad the record he already held to 11 film nominations from the guild.


Also nominated were past winners Kathryn Bigelow for her Osama bin Laden thriller "Zero Dark Thirty"; Tom Hooper for his musical "Les Miserables"; and Ang Lee for his lost-at-sea story "Life of Pi."


Rounding out the Directors Guild lineup is first-time nominee Ben Affleck for his Iran hostage-crisis tale "Argo."


The Directors Guild field is one of Hollywood's most-accurate forecasts for who will be in the running at the Academy Awards, whose nominations come out Thursday. The winner at the Directors Guild almost always goes on to win the directing prize at the Oscars, too. Only six times in the 64-year history of the guild awards has the winner there failed to follow up with an Oscar.


Besides the record number of feature-film nominations, Spielberg also has won the Directors Guild prize a record three times, for "The Color Purple," ''Schindler's List" and "Saving Private Ryan," along with directing Oscars for the latter two. He received the guild's lifetime-achievement award in 2000.


Bigelow became the first woman ever to win the guild honor and the directing Oscar three years ago for "The Hurt Locker." Hooper won the same prizes a year later for "The King's Speech," while Lee is a two-time guild winner for "Crouching Tiger, Hidden Dragon" and "Brokeback Mountain," the latter also earning him the directing Oscar.


Affleck, who also stars in "Argo," follows such actors-turned-filmmakers as Clint Eastwood, Kevin Costner and Mel Gibson to earn a Directors Guild nomination.


Overlooked by the guild were past nominees Quentin Tarantino for his slave-revenge tale "Django Unchained" and David O. Russell for his oddball romance "Silver Linings Playbook."


The film that receives the Directing Guild prize typically also goes on to win the best-picture Oscar, a prize Spielberg has earned only once, for "Schindler's List." No clear front-runner has emerged yet for the Feb. 24 Oscars, with "Lincoln," ''Zero Dark Thirty" and "Les Miserables" all considered strong prospects to take home Hollywood's highest honor.


Sunday's Golden Globes will help sort out the Oscar picture, as will the various guild prizes that will be handed out in late January and February on the run-up to the Academy Awards.


Winners for the 65th annual Directors Guild awards will be announced at a Hollywood dinner Feb. 2, with Kelsey Grammer as host for the second year in a row.


Milos Forman, director of "One Flew Over the Cuckoo's Nest" and "Amadeus," will receive the guild's lifetime-achievement award.


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Online:


http://www.dga.org


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